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panB [2017-8-11 16:0:3]
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panB [2017-8-11 16:0:3]

3-methyl-2-oxobutanoate hydroxymethyltransferase
locus
BSU22430
pI
5.28
mw
29.61 kDa
protein length
277 aa Sequence Blast
gene length
831 bp Sequence Blast
function
biosynthesis of coenzyme A
product
3-methyl-2-oxobutanoate hydroxymethyltransferase
essential
no
ec
2.1.2.11
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.4|Biosynthesis of coenzyme A]

    • Gene

    Coordinates
    2,353,839 → 2,354,672

    The protein

    Catalyzed reaction/ biological activity

  • 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = tetrahydrofolate + 2-dehydropantoate (according to Swiss-Prot)

    • Structure

  • [PDB|3EZ4] (from ''Burkholderia pseudomallei'', 44% identity, 64% similarity)

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Biological materials

    Mutant

  • PA126 (''panB''::''cat''), available in [SW|Jörg Stülke]'s lab

    • References

  • 21383089,27120414